CAR-T therapy has dramatically changed the course of cancer management over the past few years. However, despite this impact, one of the key challenges about the CAR-T therapies is its highly complex and long manufacturing process. With this lengthy manufacturing time and long wait-time, patients face higher chance of disease progression. To address this scenario, many novel platforms which promote rapid production of CAR-Ts are underway. Several steps utilized in conventiona

PD-(L)1 axis inhibits CAR-T cell activation, proliferation, survival, and functionality. Thus, CAR-T mediated direct targeting of the PD-(L)1 immunosuppressive axis or modulation of the axis along with CAR-T therapy holds a huge promise to unleash the full potential of CAR-Ts. Multiple strategies are under investigation to target PD-(L)1 immunosuppressive axis to increase CAR-T therapy efficacy. We have grouped the strategies under the following three broad categories, Combin